Tynept (Tianeptine) 12.5 mg Tablets

Tynept is our tablet listing for tianeptine, an oral atypical antidepressant supplied as 12.5 mg tablets. We carry it in 30-, 50-, 100-, and 150-tablet packages so you can pick the count that fits your planned supply.

About Tynept (Tianeptine)

Tynept's active ingredient, tianeptine, is an atypical antidepressant chemically related to the tricyclic group but pharmacologically distinct. Tianeptine and its active metabolite act as mu-opioid receptor agonists, while effects on glutamatergic signaling have also been proposed; its precise antidepressant mechanism is not fully established. Its opioid activity helps explain the recognized risks of misuse, dependence, overdose, and withdrawal. In countries where it is approved, tianeptine is prescribed for major depressive episodes, including depression accompanied by anxiety or physical symptoms.

Essential Facts and Dosing

Where tianeptine 12.5 mg tablets are approved for depression, the established adult regimen is one 12.5 mg tablet three times a day before main meals, for a total of 37.5 mg daily. Adults older than 70 and people with severe kidney impairment are generally limited to one tablet twice daily. A missed dose should not be replaced with a double dose, and the dose should not be increased without a prescriber's direction. Full antidepressant benefit may take several weeks, although some symptoms can improve sooner.

Established labeling recommends reducing the dose gradually over 7 to 14 days under medical guidance rather than stopping suddenly. Follow-up is important to assess mood, alertness, adverse effects, and any signs of misuse or dependence. As with other antidepressant treatment, new or worsening suicidal thoughts, unusual behavior changes, or marked agitation require prompt medical attention, particularly early in treatment or after a dose change.

Common effects reported with therapeutic use include dry mouth, dizziness, drowsiness, headache, mild stomach upset, constipation, sleep changes, and tremor. Tianeptine should not be used by anyone with a known allergy to tianeptine or a tablet ingredient. It must not be combined with monoamine oxidase inhibitors, and switching between these medicines requires the washout period directed by a prescriber. Alcohol, opioids, and other sedatives can worsen impairment and may increase the risk of overdose or breathing problems.

Available Strengths and Package Sizes

Every Tynept package we sell contains the same 12.5 mg oral tablet; only the tablet count changes. This lets you compare a smaller 30- or 50-tablet package with the 100- and 150-tablet options while keeping the strength and dosage form consistent.

Important Safety Notes

• Store tablets below 86°F in the original package, protected from moisture, and out of reach of children.
• Tianeptine can cause drowsiness, dizziness, or reduced alertness, especially when treatment starts, so do not drive or operate machinery until you know how it affects you.
• Established product information advises avoiding tianeptine during pregnancy and breastfeeding, and no pediatric use or dosing is established for these tablets.
• Do not take more than the prescribed amount. Seeking progressively larger doses, using the tablets for effects other than prescribed, or feeling unable to reduce use can indicate dependence and requires medical help.
• Slow or shallow breathing, extreme drowsiness, inability to wake, confusion, or a seizure after tianeptine use requires immediate emergency assistance.
• Tianeptine is not authorized for human medicinal use in the United States, and the FDA has warned consumers against buying or using tianeptine-containing products because of opioid-receptor activity, abuse, dependence, withdrawal, and reported seizures and deaths; this differs from its status as an approved antidepressant in some other countries.

Our pharmacist-supported team is available 24/7 by email, chat, or phone if you have questions about pack sizes, storage, or placing your Tynept order. If you would like to compare other antidepressant options, our AntiDepressants category lists additional treatments we carry.