Zyban (Bupropion) 150 mg Sustained-Release Tablets

Zyban is the brand name for bupropion in a 150 mg sustained-release tablet, taken by mouth. We carry this exact formulation and strength, with package sizes ranging from 10 to 360 tablets so customers can match an order to their planned course of treatment. This guide walks through what to confirm before starting, how to handle and store the tablets correctly, and what happens when you place an order with us.

Quick Overview: What Zyban Is and How It Works

Bupropion belongs to the aminoketone class and works differently from most antidepressants: it primarily affects norepinephrine and dopamine reuptake rather than serotonin. Bupropion is used for major depressive disorder in products labeled for that purpose and, under the Zyban brand, as a smoking-cessation aid. When used to help someone stop smoking, it is thought to reduce nicotine cravings and withdrawal symptoms by acting on reward pathways also affected by nicotine.

Because the tablet is sustained-release, it delivers bupropion gradually over several hours. A common adult smoking-cessation schedule starts with 150 mg once daily for three days and then increases to 150 mg twice daily, with doses at least eight hours apart and a maximum of 300 mg per day. The prescriber's directions take priority because individual dosing may differ. We offer Zyban only in the 150 mg strength, consistent with how sustained-release bupropion for smoking cessation is typically supplied.

Who May Use Zyban

Zyban is intended for adults using bupropion as part of a smoking-cessation plan. It should not be treated as interchangeable with bupropion products labeled for depression without direction from a prescriber. Treatment typically begins about one to two weeks before a planned quit date, allowing time for the medicine to begin affecting cravings and withdrawal symptoms. Zyban is not approved for use in children or adolescents, and safety and effectiveness in that age group have not been established.

Certain health conditions make bupropion unsuitable or require extra caution. It should not be used by someone with a seizure disorder, a current or previous diagnosis of anorexia nervosa or bulimia, or someone abruptly discontinuing alcohol, benzodiazepines, barbiturates, or antiepileptic medicines. People should not take Zyban together with another medicine containing bupropion. Diabetes managed with insulin or oral hypoglycemic medicines can further increase seizure risk and should be reviewed with a healthcare provider before treatment. People with a known hypersensitivity to bupropion or any tablet ingredient should not take it.

Pregnant or breastfeeding patients should talk to a clinician before use. Bupropion and its metabolites pass into human milk, and the balance between treating nicotine dependence and potential risk requires individual judgment. Readers managing depression as well as a smoking-cessation goal may find information about separately prescribed options in our AntiDepressants selection, while those focused on stopping smoking can browse our Quit Smoking treatments for other approaches.

Before You Start: What to Check and Prepare

Before taking the first tablet, review any seizure risk factors, current medicines, blood pressure concerns, and alcohol use with a prescriber or pharmacist. Bupropion must not be used with a monoamine oxidase inhibitor (MAOI) or within 14 days of stopping one. It can also interact with certain antidepressants, antipsychotics, medicines metabolized by CYP2D6, and other drugs that lower the seizure threshold. Alcohol should generally be minimized or avoided as directed because sudden changes in alcohol use can increase the risk of adverse effects.

Common adverse effects include insomnia, dry mouth, nausea, dizziness, agitation, and headache. Blood pressure may rise, particularly when bupropion is combined with nicotine-replacement therapy, so monitoring may be appropriate. Seek prompt medical help for a seizure, severe allergic reaction, marked behavioral or mood changes, suicidal thoughts, hallucinations, or other serious symptoms. Bupropion can also affect judgment, coordination, or concentration, so patients should avoid driving or operating hazardous machinery until they know how it affects them.

Set a realistic quit date if Zyban is being used for smoking cessation. Take each tablet exactly as prescribed and swallow it whole. If a dose is missed, skip it rather than taking an extra tablet, because doses taken too close together increase seizure risk.

Handling and Storing Your Tablets

Sustained-release tablets are engineered to release bupropion gradually, so the tablet's coating and structure matter. Tablets should always be swallowed whole; cutting, crushing, or chewing a sustained-release tablet can break down that slow-release mechanism and cause too much of the medicine to be absorbed at once, raising the risk of adverse effects, including seizures.

Keep Zyban in its original, tightly closed container, away from direct light and moisture. Store it at 68°F to 77°F, with brief excursions from 59°F to 86°F permitted, including during transit. Bathrooms and areas with high humidity are best avoided for long-term storage. Keep the tablets out of the reach and sight of children at all times, and dispose of unused or expired tablets according to local guidance rather than keeping them indefinitely.

Ordering and Delivery With Us

Zyban sustained-release tablets are prescription medicines in the United States, and bupropion is authorized for human medicinal use. We list the 150 mg sustained-release tablet in package sizes of 10, 20, 30, 60, 90, 120, 180, 270, and 360 tablets, allowing customers to select from the quantities currently offered. To confirm what information we need to accept and process your order, contact our support team before checkout.

Our support team is available 24/7 by email, online chat, or phone, and a pharmacist is available to answer questions about your order or the appropriate use of Zyban. Once an order is confirmed, we pack it securely and discreetly, without exterior labeling that identifies the contents, and send it to your home address or private mailbox. If you have questions about a specific package size, current pricing, or delivery timing for your location, our support channels are the fastest way to get clear answers before you commit to an order. For background on the active ingredient across other formulations, you can also read our bupropion information.